The longer you have glucose sitting around in your vascular system, it reacts with proteins, with DNA, lipids, but specifically it reacts with proteins, including collagen ... It forms something called Advanced Glycation End Products, or AGEs for short. And these things, they basically, cause your proteins to become stiff ... One of the reasons that exercise plays an important role in de-stiffening the heart or preventing the stiffness is because of the just enormous improvement in glucose regulation that you're getting from exercise.